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Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

《医学前沿（英文）》 2021年 第15卷 第2期   页码 170-177 doi: 10.1007/s11684-020-0747-z

摘要： Nanosecond pulsed electric field (nsPEF) is a novel, nonthermal, and minimally invasive modality that can ablate solid tumors by inducing apoptosis. Recent animal experiments show that nsPEF can induce the immunogenic cell death of hepatocellular carcinoma (HCC) and stimulate the host’s immune response to kill residual tumor cells and decrease distant metastatic tumors. nsPEF-induced immunity is of great clinical importance because the nonthermal ablation may enhance the immune memory, which can prevent HCC recurrence and metastasis. This review summarized the most advanced research on the effect of nsPEF. The possible mechanisms of how locoregional nsPEF ablation enhances the systemic anticancer immune responses were illustrated. nsPEF stimulates the host immune system to boost stimulation and prevail suppression. Also, nsPEF increases the dendritic cell loading and inhibits the regulatory responses, thereby improving immune stimulation and limiting immunosuppression in HCC-bearing hosts. Therefore, nsPEF has excellent potential for HCC treatment.

关键词： nanosecond pulsed electric fields (nsPEF)     hepatocellular carcinoma (HCC)     immune response     recurrence     metastasis    

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Design and analysis of electrothermal metasurfaces

Xiu LIU, Zhuo LI, Zexiao WANG, Hyeong Seok YUN, Sheng SHEN

《能源前沿（英文）》 2023年 第17卷 第1期   页码 134-140 doi: 10.1007/s11708-022-0841-9

摘要： Electrothermal metasurfaces have garnered considerable attention owing to their ability to dynamically control thermal infrared radiation. Although previous studies were mainly focused on metasurfaces with infinite unit cells, in practice, the finite-size effect can be a critical design factor for developing thermal metasurfaces with fast response and broad temperature uniformity. Here, we study the thermal metasurfaces consisting of gold nanorods with a finite array size, which can achieve a resonance close to that of the infinite case with only several periods. More importantly, such a small footprint due to the finite array size yields response time down to a nanosecond level. Furthermore, the number of the unit cells in the direction perpendicular to the axis of nanorods is found to be insensitive to the resonance and response time; thus, providing a tunable aspect ratio that can boost the temperature uniformity in the sub-Kelvin level.

关键词： modulated thermal infrared radiation     metasurface     nanosecond response time     sub-Kelvin temperature uniformity     finite size     aspect ratio    

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Synthesis of Ag and Cd nanoparticles by nanosecond pulsed discharge in liquid nitrogen

Mahmoud Trad, Alexandre Nominé, Natalie Tarasenka, Jaafar Ghanbaja, Cédric Noël, Malek Tabbal, Thierry Belmonte

《化学科学与工程前沿（英文）》 2019年 第13卷 第2期   页码 360-368 doi: 10.1007/s11705-019-1802-7

摘要： The synthesis of CdO, Ag O (5 nm) and Ag (~20‒30 nm) nano-objects is achieved simultaneously by nanosecond-pulsed discharges in liquid nitrogen between one cadmium electrode and one silver electrode. Oxidation occurs when liquid nitrogen is fully evaporated and nanoparticles are in contact with the air. No alloy is formed, whatever the conditions, even though both elements are present simultaneously, as showed by time-resolved optical emission spectroscopy. This lack of reactivity between elements is attributed to the high pressure within the discharge that keeps each metallic vapor around the electrode it comes from. Each element exhibits a specific behavior. Cubic Cd particles, formed at 4 kV, get elongated with filamentary tips when the applied voltage reaches 7 and 10 kV. Cd wires are formed by assembly in liquid nitrogen of Cd nanoparticles driven by dipole assembly, and not by dielectrophoresis. On the contrary, silver spherical particles get assembled into 2D dendritic structures. The anisotropic growth of these structures is assumed to be due to the existence of pressure gradients.

关键词： spark discharges     submerged discharges     time-resolved optical emission spectroscopy     liquid nitrogen    

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Physics-Informed Deep Learning-Based Real-Time Structural Response Prediction Method

Ying Zhou,Shiqiao Meng,Yujie Lou,Qingzhao Kong,

《工程（英文）》 doi: 10.1016/j.eng.2023.08.011

摘要： High-precision and efficient structural response prediction is essential for intelligent disaster prevention and mitigation in building structures, including post-earthquake damage assessment, structural health monitoring, and seismic resilience assessment of buildings. To improve the accuracy and efficiency of structural response prediction, this study proposes a novel physics-informed deep-learning-based real-time structural response prediction method that can predict a large number of nodes in a structure through a data-driven training method and an autoregressive training strategy. The proposed method includes a Phy-Seisformer model that incorporates the physical information of the structure into the model, thereby enabling higher-precision predictions. Experiments were conducted on a four-story masonry structure, an eleven-story reinforced concrete irregular structure, and a twenty-one-story reinforced concrete frame structure to verify the accuracy and efficiency of the proposed method. In addition, the effectiveness of the structure in the Phy-Seisformer model was verified using an ablation study. Furthermore, by conducting a comparative experiment, the impact of the range of seismic wave amplitudes on the prediction accuracy was studied. The experimental results show that the method proposed in this paper can achieve very high accuracy and at least 5000 times faster calculation speed than finite element calculations for different types of building structures.

关键词： Structural seismic response prediction     Physics information informed     Real-time prediction     Earthquake engineering     Data-driven machine learning    

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Damage identification in connections of moment frames using time domain responses and an optimization

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 851-866 doi: 10.1007/s11709-021-0739-3

摘要： Damage is defined as changes to the material and/or geometric properties of a structural system, comprising changes to the boundary conditions and system connectivity, adversely affecting the system’s performance. Inspecting the elements of structures, particularly critical components, is vital to evaluate the structural lifespan and safety. In this study, an optimization-based method for joint damage identification of moment frames using the time-domain responses is introduced. The beam-to-column connection in a metallic moment frame structure is modeled by a zero-length rotational spring at both ends of the beam element. For each connection, an end-fixity factor is specified, which changes between 0 and 1. Then, the problem of joint damage identification is converted to a standard optimization problem. An objective function is defined using the nodal point accelerations extracted from the damaged structure and an analytical model of the structure in which the nodal accelerations are obtained using the Newmark procedure. The optimization problem is solved by an improved differential evolution algorithm (IDEA) for identifying the location and severity of the damage. To assess the capability of the proposed method, two numerical examples via different damage scenarios are considered. Then, a comparison between the proposed method and the existing damage identification method is provided. The outcomes reveal the high efficiency of the proposed method for finding the severity and location of joint damage considering noise effects.

关键词： damage identification     beam-to-column connection     time-domain response     optimization    

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Enhancement of the polynomial functions response surface model for real-time analyzing ozone sensitivity

Jiangbo Jin, Yun Zhu, Jicheng Jang, Shuxiao Wang, Jia Xing, Pen-Chi Chiang, Shaojia Fan, Shicheng Long

《环境科学与工程前沿（英文）》 2021年 第15卷 第2期 doi: 10.1007/s11783-020-1323-0

摘要： Abstract • The calculation process and algorithm of response surface model (RSM) were enhanced. • The prediction errors of RSM in the margin and transition areas were greatly reduced. • The enhanced RSM was able to analyze O3-NOx-VOC sensitivity in real-time. • The O3 formations were mainly sensitive to VOC, for the two case study regions. Quantification of the nonlinearities between ambient ozone (O3) and the emissions of nitrogen oxides (NOx) and volatile organic compound (VOC) is a prerequisite for an effective O3 control strategy. An Enhanced polynomial functions Response Surface Model (Epf-RSM) with the capability to analyze O3-NOx-VOC sensitivities in real time was developed by integrating the hill-climbing adaptive method into the optimized Extended Response Surface Model (ERSM) system. The Epf-RSM could single out the best suited polynomial function for each grid cell to quantify the responses of O3 concentrations to precursor emission changes. Several comparisons between Epf-RSM and pf-ERSM (polynomial functions based ERSM) were performed using out-of-sample validation, together with comparisons of the spatial distribution and the Empirical Kinetic Modeling Approach diagrams. The comparison results showed that Epf-RSM effectively addressed the drawbacks of pf-ERSM with respect to over-fitting in the margin areas and high biases in the transition areas. The O3 concentrations predicted by Epf-RSM agreed well with Community Multi-scale Air Quality simulation results. The case study results in the Pearl River Delta and the north-western area of the Shandong province indicated that the O3 formations in the central areas of both the regions were more sensitive to anthropogenic VOC in January, April, and October, while more NOx-sensitive in July.

关键词： Response surface model     Hill-climbing algorithm     Ozone pollution     Precursor emissions     Control strategy    

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Attuned design of demand response program and M-FACTS for relieving congestion in a restructured market

Y. HASHEMI,H. SHAYEGHI,B. HASHEMI

《能源前沿（英文）》 2015年 第9卷 第3期   页码 282-296 doi: 10.1007/s11708-015-0366-6

摘要： This paper addresses the attuned use of multi-converter flexible alternative current transmission systems (M-FACTS) devices and demand response (DR) to perform congestion management (CM) in the deregulated environment. The strong control capability of the M-FACTS offers a great potential in solving many of the problems facing electric utilities. Besides, DR is a novel procedure that can be an effective tool for reduction of congestion. A market clearing procedure is conducted based on maximizing social welfare (SW) and congestion as network constraint is paid by using concurrently the DR and M-FACTS. A multi-objective problem (MOP) based on the sum of the payments received by the generators for changing their output, the total payment received by DR participants to reduce their load and M-FACTS cost is systematized. For the solution of this problem a nonlinear time-varying evolution (NTVE) based multi-objective particle swarm optimization (MOPSO) style is formed. Fuzzy decision-making (FDM) and technique for order preference by similarity to ideal solution (TOPSIS) approaches are employed for finding the best compromise solution from the set of Pareto-solutions obtained through multi-objective particle swarm optimization-nonlinear time-varying evolution (MOPSO-NTVE). In a real power system, Azarbaijan regional power system of Iran, comparative analysis of the results obtained from the application of the DR & unified power flow controller (UPFC) and the DR & M-FACTS are presented.

关键词： multi-converter flexible alternative current transmission systems (M-FACTS)     demand response     fuzzy decision making     multi-objective particle swarm optimization-nonlinear time-varying evolution (MOPSO-NTVE)    

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On subsurface box-shaped lined tunnel under incident SH-wave propagation

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 948-960 doi: 10.1007/s11709-021-0740-x

摘要： In this paper, a half-plane time-domain boundary element method is applied to obtain the seismic ground response, including a subsurface box-shaped lined tunnel deployed in a linear homogenous elastic medium exposed to obliquely incident SH-waves. Only the boundary around the tunnel is required to be discretized. To prepare an appropriate model by quadratic elements, a double-node procedure is used to receive dual boundary fields at corners as well as change the direction of the normal vector. After encoding the method in a previously confirmed computer program, a numerical study is carried out to sensitize some effective parameters, including frequency content and incident wave angle for obtaining a surface response. The depth and impedance ratio of the lining are assumed to be unvaried. The responses are illustrated in the time and frequency domains as two/three-dimensional graphs. The results showed that subsurface openings with sharp corners distorted the propagation path of the anti-plane waves to achieve the critical states on the ground surface. The present approach can be proposed to civil engineers for preparing simple underground box-shaped models with angular boundaries.

关键词： box-lined tunnel     half-plane BEM     surface response     SH-wave     time-domain    

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火灾中闭式喷头响应特性研究

张村峰,霍然,李元洲

《中国工程科学》 2005年 第7卷 第11期   页码 55-59

摘要：

探讨了火灾时闭式喷头的响应时间和启动闭式喷头的临界火源功率，通过分析计算，给出了喷头启动时间与各种影响因素的拟合公式。结果表明：响应时间与安装高度、环境温度呈近似线性关系；火灾增长方式对响应时间的增长快慢产生影响；喷头的响应时间常数与响应时间则成指数关系。随着高度增加，喷头启动的临界火源功率不断增大，当喷头安装高度较高时，为早期有效的控制火灾，必须采用快速响应喷头。

关键词： 喷头     临界热释放速率     响应时间    

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Seismic performance of steel MRF building with nonlinear viscous dampers

Baiping DONG,James M. RICLES,Richard SAUSE

《结构与土木工程前沿（英文）》 2016年 第10卷 第3期   页码 254-271 doi: 10.1007/s11709-016-0348-8

摘要： This paper presents an experimental study of the seismic response of a 0.6-scale three-story seismic-resistant building structure consisting of a moment resisting frame (MRF) with reduced beam sections (RBS), and a frame with nonlinear viscous dampers and associated bracing (called the DBF). The emphasis is on assessing the seismic performance for the design basis earthquake (DBE) and maximum considered earthquake (MCE). Three MRF designs were studied, with the MRF designed for 100%, 75%, and 60%, respectively, of the required base shear design strength determined according to ASCE 7-10. The DBF with nonlinear viscous dampers was designed to control the lateral drift demands. Earthquake simulations using ensembles of DBE and MCE ground motions were conducted using the real-time hybrid simulation method. The results show the drift demand and damage that occurs in the MRF under seismic loading. Overall, the results show that a high level of seismic performance can be achieved under DBE and MCE ground motions, even for a building structure designed for as little as 60% of the base shear design strength required by ASCE 7-10 for a structure without dampers.

关键词： seismic response     steel MRF     nonlinear viscous damper     design basis earthquake     real-time hybrid simulation    

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Analysis of planetary gear transmission in non-stationary operations

Fakher CHAARI, Mohamed Slim ABBES, Fernando Viadero RUEDA, Alfonso Fernandez del RINCON, Mohamed HADDAR

《机械工程前沿（英文）》 2013年 第8卷 第1期   页码 88-94 doi: 10.1007/s11465-013-0361-8

摘要：

Planetary gearboxes operate usually in non-stationary conditions generated mainly by variable loads applied to these transmissions. In order to understand the dynamic behavior of planetary gearboxes in such conditions, a mathematic model is developed including driving unit, transmission and load. The variability of load induces a variable speed of the transmission which is taken into account when characterizing the main dynamic parameter of the transmission which is the mesh stiffness function. This function is not periodic following the variability of the transmission speed. The computation of the dynamic response shows an intimate relation between the vibration amplitude level and the load value. As the load increase the vibration level increase. A combined amplitude and frequency modulation is observed which is well characterized using Short Time Fourier transform more suited than the spectral analysis.

关键词： planetary gearbox     non-stationary conditions     variable load     dynamic response     time frequency analysis    

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基于CAN总线的TT-FPS调度算法研究及其性能分析

吕伟杰,刘鲁源,王毅新

《中国工程科学》 2006年 第8卷 第5期   页码 45-48

摘要：

针对CAN总线中消息在固定优先级调度（FPS）算法下传输不可预知、低优先级消息容易被阻塞的问题，提出了一种基于时间触发机制的固定优先级调度（TT-FPS）算法，给出了最糟糕响应时间的计算方法。然后以纯电动汽车消息系统为例进行了TT-FPS的性能分析，验证了TT-FPS 较FPS有更好的性能。

关键词： CAN总线     TT-FPS     最糟糕响应时间    

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Seismic analysis of a super high-rise steel structure with horizontal strengthened storeys

Yuanqing WANG, Hui ZHOU, Yongjiu SHI, Yi HUANG, Gang SHI, Siqing WEN

《结构与土木工程前沿（英文）》 2011年 第5卷 第3期   页码 394-404 doi: 10.1007/s11709-011-0116-8

摘要： Horizontal strengthened storeys are widely used in super high-rise steel structures to improve the lateral structural rigidity. This use has great effects on the seismic properties of the entire structure. The seismic properties of the Wuhan International Securities Building (a 68-storey super high-rise steel structure with three horizontal strengthened storeys) were evaluated in this study. Two approaches, i.e., mode-superposition response spectrum analysis and time-history analysis, were employed to calculate the seismic response of the structure. The response spectrum analysis indicated that transition parts near the three strengthened storeys were weak zones of the structure because of the abrupt change in rigidity. In the response spectrum analysis approach, the Square Root of Sum of Square (SRSS) method was recommended when the vertical seismic effects could be ignored. However, the complete quadratic combination (CQC) method was superior to SRSS method when the vertical seismic effects should be considered. With the aid of time-history analysis, the seismic responses of the structure were obtained. The whiplash effect that spectrum analysis cannot reveal was observed through time-history analysis. This study provides references for the seismic design of super high-rise steel structures with horizontal strengthened storeys.

关键词： seismic analysis     steel structure     super high-rise     horizontal strengthened storey     response spectrum analysis     time-history analysis    

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Enhanced dewatering characteristics of waste activated sludge with Fenton pretreatment: effectiveness and statistical optimization

Guangyin ZHEN, Xueqin LU, Baoying WANG, Youcai ZHAO, Xiaoli CHAI, Dongjie NIU, Tiantao ZHAO

《环境科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 267-276 doi: 10.1007/s11783-013-0530-3

摘要： In this work, the enhanced dewaterabing characteristics of waste activated sludge using Fenton pretreatment was investigated in terms of effectiveness and statistical optimization. Response surface method (RSM) and central composite design (CCD) were applied to evaluate and optimize the effectiveness of important operational parameters, i.e., H O concentrations, Fe concentrations and initial pH values. A significant quadratic polynomial model was obtained ( 0.9189) with capillary suction time (CST) reduction efficiency as the response. Numerical optimization based on desirability function was carried out. The optimum values for H O , Fe , and initial pH were found to be 178 mg·g VSS (volatile suspended solids), 211 mg·g VSS and 3.8, respectively, at which CST reduction efficiency of 98.25% could be achieved. This complied well with those predicted by the established polynomial model. The results indicate that Fenton pretreatment is an effective technique for advanced waste activated sludge dewatering. The enhancement of sludge dewaterability by Fenton’s reagent lies in the migration of sludge bound water due to the disintegration of sludge flocs and microbial cells lysis.

关键词： Fenton pretreatment     response surface methodology (RSM)     capillary suction time (CST)     dewaterabilty     molecular weight distribution    

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考虑输入噪声的混合调制拉格朗日明确时延估计改进算法 Article

Wei XIA,Ju-lei ZHU,Wen-ying JIANG,Ling-feng ZHU

《信息与电子工程前沿（英文）》 2016年 第17卷 第10期   页码 1067-1073 doi: 10.1631/FITEE.1500417

摘要： 概要：混合调制拉格朗日明确时延估计（mixed modulated Lagrange explicit time delay estimation, MMLETDE）算法可对窄带信号或正弦信号提供有效的时延估计

关键词： 时延估计；自适应滤波器；噪声输入；调制拉格朗日法；无偏脉冲响应估计    

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标题 作者 时间 类型 操作

Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

期刊论文

Design and analysis of electrothermal metasurfaces

Xiu LIU, Zhuo LI, Zexiao WANG, Hyeong Seok YUN, Sheng SHEN

期刊论文

Synthesis of Ag and Cd nanoparticles by nanosecond pulsed discharge in liquid nitrogen

Mahmoud Trad, Alexandre Nominé, Natalie Tarasenka, Jaafar Ghanbaja, Cédric Noël, Malek Tabbal, Thierry Belmonte

期刊论文

Physics-Informed Deep Learning-Based Real-Time Structural Response Prediction Method

Ying Zhou,Shiqiao Meng,Yujie Lou,Qingzhao Kong,

期刊论文

Damage identification in connections of moment frames using time domain responses and an optimization

期刊论文

Enhancement of the polynomial functions response surface model for real-time analyzing ozone sensitivity

Jiangbo Jin, Yun Zhu, Jicheng Jang, Shuxiao Wang, Jia Xing, Pen-Chi Chiang, Shaojia Fan, Shicheng Long

期刊论文

Attuned design of demand response program and M-FACTS for relieving congestion in a restructured market

Y. HASHEMI,H. SHAYEGHI,B. HASHEMI

期刊论文

On subsurface box-shaped lined tunnel under incident SH-wave propagation

期刊论文

火灾中闭式喷头响应特性研究

张村峰,霍然,李元洲

期刊论文

Seismic performance of steel MRF building with nonlinear viscous dampers

Baiping DONG,James M. RICLES,Richard SAUSE

期刊论文

Analysis of planetary gear transmission in non-stationary operations

Fakher CHAARI, Mohamed Slim ABBES, Fernando Viadero RUEDA, Alfonso Fernandez del RINCON, Mohamed HADDAR

期刊论文

基于CAN总线的TT-FPS调度算法研究及其性能分析

吕伟杰,刘鲁源,王毅新

期刊论文

Seismic analysis of a super high-rise steel structure with horizontal strengthened storeys

Yuanqing WANG, Hui ZHOU, Yongjiu SHI, Yi HUANG, Gang SHI, Siqing WEN

期刊论文

Enhanced dewatering characteristics of waste activated sludge with Fenton pretreatment: effectiveness and statistical optimization

Guangyin ZHEN, Xueqin LU, Baoying WANG, Youcai ZHAO, Xiaoli CHAI, Dongjie NIU, Tiantao ZHAO

期刊论文

考虑输入噪声的混合调制拉格朗日明确时延估计改进算法

Wei XIA,Ju-lei ZHU,Wen-ying JIANG,Ling-feng ZHU

期刊论文